US 11,185,499 B2Granted

Multilayer thin film drug delivery device and methods of making and using the same

AssigneeThe Regents of the University of California

InventorsTejal Ashwin Desai, Mark Rory Steedman, Robert Bhisitkul, Daniel A. Bernards, Kevin D. Lance

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Abstract

Multilayer thin film devices that include a bioactive agent for elution to the surrounding tissue upon administration to a subject are provided. The multilayer thin film devices are useful as medical devices, such as ocular devices. Also provided are methods and kits for localized delivery of a bioactive agent to a tissue of a subject, and methods of preparing the subject devices. The multilayer thin film medical device includes a first layer, a bioactive agent and a second layer. The first and the second layers may be porous or non-porous. The devices have a furled structure, suitable for administration to a subject.

Claims16

Dependent claims

A method for delivering at least two bioactive agents into an eye of a subject having an ocular condition, the method comprising:

inserting into an eye of the subject a thin-film device comprising at least two bioactive agents, the device comprising a biodegradable polymer layer enclosing the at least two bioactive agents,
wherein the at least two bioactive agents are not present in the biodegradable polymer layer,
wherein the device provides a zero-order release of the at least two bioactive agents in the eye for a period of at least 3 months, and
wherein the biodegradable polymer layer is a nanoporous layer comprising engineered nanopores, wherein the device comprises a microporous backing layer that supports the nanoporous layer, wherein the at least two bioactive agents are in contact with the nanoporous layer.

1 more element

Dependencies are inferred from the claim text.

Facts

Application: 16/851,735Filed 17 Apr 2020 · continuation
Priority: 14 Apr 2011
Published: US 2020/0261357 A18 Oct 2020
Granted: 30 Nov 2021
Term ends: Not estimatedThe source records don’t support an estimate.

Classification21 codes

A61K 9/0048
Galenical forms characterised by the site of application: eye, e.g. artificial tears
A61F 9/0017
Introducing ophthalmic products into the ocular cavity or retaining products therein: implantable in, or in contact with, the eye, e.g. ocular inserts
A61K 9/0051
Eye, e.g. artificial tears: ocular inserts or implants
A61K 9/7007
Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug: drug-containing films, membranes or sheets

Family

Application61/475,373Us provisional application · filed 14 Apr 2011
PCT/US2012/033366Parent of this continuation · filed 12 Apr 2012
Application16/815,509Parent of this continuation · filed 11 Mar 2020
US 2020/0315961 A1Pre-grant publication · published 8 Oct 2020
Application14/110,549Parent of this continuation
US 10,864,158 B2Parent of this continuation
US 11,185,498 B2Related patent
US 2014/0170204 A1Published application
US 2020/0261357 A1Published application
US 11,185,499 B2This patent

From the US filing history. Foreign family members aren’t listed.