Measurement apparatus
AssigneeAdvantest Corporation
InventorNobuei Washizu
Life of this patent
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Abstract
A nanopore device measures a current signal Is that flows through the nanopore device, which has an aperture and an electrode pair. A transimpedance amplifier converts the current signal Is into a voltage signal Vs. A voltage source is configured to apply a DC bias voltage Vb across the electrode pair in a normal measurement mode, and to apply a calibration voltage Vcal across the electrode pair in a calibration mode. In the calibration mode, at least one circuit constant of a measurement apparatus is calibrated based on the output signal Vs of the transimpedance amplifier and the calibration voltage Vcal.
Claims13
A measurement apparatus structured to measure a current signal that flows through a nanopore device having an aperture and an electrode pair, the measurement apparatus comprising:
- a transimpedance amplifier structured to convert the current signal into a voltage signal;
- and
- a voltage source structured to apply a DC bias voltage across the electrode pair in a normal measurement operation mode, and to apply a calibration voltage including an AC component across the electrode pair in a calibration mode,
- wherein, in the normal measurement operation mode, the nanopore device includes particles to be detected,
- and wherein in the calibration mode, the nanopore device does not include particles to be detected and at least one circuit constant of the measurement apparatus can be calibrated based on an output signal of the transimpedance amplifier and the calibration voltage.
Dependencies are inferred from the claim text.