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US 11,180,523 B2Granted
Design, synthesis and use of synthetic nucleotides comprising charge mass tags
AssigneeQuantumdx Group Limited
InventorsJonathan J. O'Halloran, Joseph H. Hedley
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Abstract
Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.
Claims15
A reporter composition, comprising:
- a nucleotide or its derivative;
- a high charge mass moiety comprising one or more charged entities selected from the group consisting of the following compounds 1-5, and any combinations thereof:
- wherein the one or more charged entities is arrayed dendritically, and
- wherein the compounds comprise a charge mass that is sufficient to generate a detectable change in a property of a sensitive detection structure operably coupled to the reporter composition.
1 more element
Dependencies are inferred from the claim text.