Synthesis of 4-aminopyrimidine compounds

A process for manufacturing 2-isobutyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine of Formula (I):

• said process comprising the following steps:
• (a) reacting 6-chloro-2-isobutylpyrimidin-4-amine of Formula (III):
• with a N-protected N-methylazetidin-3-amine of Formula (IV):
• wherein RP is a protecting group selected from Carbobenzyloxy (Cbz), p-Methoxybenzyl carbonyl (Moz), tert-Butyloxycarbonyl (Boc), 9-Fluorenylmethyloxycarbonyl (Fmoc), Acetyl (Ac), Benzoyl (Bz), Benzyl (Bn), Carbamate, p-Methoxybenzyl (PMB), 3,4-Dimethoxybenzyl (DMPM), p-Methoxyphenyl (PMP), Tosyl (Ts), and Trichloroethyl chloroformate (Troc);
• in an organic solvent, wherein said organic solvent is dimethylsulfoxide;
• in the presence of a base, wherein said base is potassium carbonate;
• at a temperature ranging from 85 to 125° C.;
• the initial molar ratio between said compound of Formula (IV) and said compound of Formula (III) ranging from 0.85 to 1.25;
• so as to obtain an intermediate protected compound of Formula (II):
• and
• (b) performing a N-deprotection of said compound of Formula (II);
• so as to obtain said compound of Formula (I).