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US 11,180,455 B2Granted
Compounds for the treatment of pain
AssigneeAlkermes, Inc.
InventorsThomas Andrew Wynn, Juan C. Alvarez, Demetri Theodore Moustakas, Markus Haeberlein, Lewis D. Pennington
Life of this patent
Estimating the term…
Abstract
Provided herein are compounds that are useful in the treatment of pain in a subject.
Claims16
A compound of Formula IV:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is C1-2 alkoxy, wherein the C1-2 alkoxy is optionally substituted with 1, 2, or 3 halo substituents;
- R2 is hydrogen, C1-6 alkyl, C3-10 cycloalkyl, 4- to 12-membered heterocycloalkyl, C1-4 alkylene-CF3, C1-4 alkylene-(C3-10 cycloalkyl), C1-4 alkylene-(4- to 12-membered heterocycloalkyl), C1-4 alkylene-(5- to 14-membered heteroaryl), or (C3-10 cycloalkylene)-(C6-14 aryl);
- wherein each of the C1-6 alkyl, C3-10 cycloalkyl, 4- to 12-membered heterocycloalkyl, C1-4 alkylene, C3-10 cycloalkylene, C6-14 aryl, and 5- to 14-membered heteroaryl of R2 is unsubstituted or substituted with 1 or 2 substituents independently selected from the group consisting of —OH, halo, C1-4 alkyl, C1-4 alkoxy, —C(═O)—(C1-4 alkyl), and —S(═O)2—(C1-4 alkyl);
- or
- wherein the C3-10 cycloalkyl, 5- to 14-membered heteroaryl, or 4- to 12-membered heterocycloalkyl of R2 is optionally substituted with 1, 2, or 3 oxo moieties;
- and
- R3 is hydrogen, OH, halo, C1-4 alkyl, or C1-4 alkoxy.
5 more elements
Dependencies are inferred from the claim text.