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US 11,180,438 B2Granted
Compositions of polyhydroxylated benzophenones and methods of treatment of neurodegenerative disorders
AssigneesMassachusetts Institute of Technology, The General Hospital Corporation
InventorsLi-Huei Tsai, Stephen J. Haggarty, Debasis Patnaik, Ping-Chieh Pao
Life of this patent
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Abstract
The present invention relates to polyhydroxylated benzophenone compounds useful in the treatment of neurodegenerative, neurological, psychiatric, and cognitive diseases, in particular those associated with a deficiency in HDAC1 deacetylase activity.
Claims21
A compound of Formula II:
- or a pharmaceutically acceptable salt, hydrate, solvate, or tautomer thereof, wherein:
- each R7, R8, R9, R10, R11, R12, R13, R14, R15 and R16 is independently H, OH, or or halogen provided that:
- (1) any two of R7, R8, R9, R10 and R11 and any two of R12, R13, R14, R15 and R16 are 2 adjacent OH groups;
- and
- (2) the compound is not:
2 more elements
Dependencies are inferred from the claim text.