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US 11,179,708 B2Granted
Compositions and methods for selective carbonylation of heterocyclic compounds
AssigneeMassachusetts Institute of Technology
InventorsYuriy Román-Leshkov, Mircea Dinca, Hoyoung Park
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Abstract
Compositions comprising metal organic frameworks and related methods and uses are generally provided, including use in selective carbonylation of heterocyclic compounds.
Claims13
A composition, comprising:
- a metal organic framework compound comprising a plurality of metal ions, each coordinated with at least one ligand;
- and
- a plurality of Co(CO)4− anions associated with at least a portion of the metal ions.
A method of synthesizing a composition, comprising:
- exposing a metal organic framework (MOF) comprising a plurality of metal ions, each coordinated with at least one ligand, to a solution comprising a plurality of Co(CO)4− anions, thereby forming a composition comprising the MOF having at least a portion of the metal ions associated with a Co(CO)4− anion.
A method comprising,
- exposing carbon monoxide and an epoxide substrate having the formula,
- to a composition comprising a metal organic framework compound comprising a plurality of metal ions, each coordinated with at least one ligand, and a plurality of Co(CO)4− anions associated with at least a portion of the metal ions, thereby forming a β-lactone having the formula,
- wherein R and R′ are the same or different and are hydrogen, an optionally substituted aliphatic group, an optionally substituted heteroaliphatic group, or an optionally substituted aromatic groups, or R and R′ join to form an optionally substituted alicyclic compound;
- and
- forming a product having the formula,
- from the β-lactone having the formula,
- upon further exposure to the composition, wherein the product is formed with a selectivity of at least about 50%.
4 more elements
A method, comprising:
- exposing carbon monoxide and a β-lactone having the formula,
- to a composition comprising a metal organic framework compound comprising a plurality of metal ions, each coordinated with at least one ligand, and a plurality of Co(CO)4− anions associated with at least a portion of the metal ions, thereby forming a product having the formula,
- wherein R and R′ are the same or different and are hydrogen, an optionally substituted aliphatic group, an optionally substituted heteroaliphatic group, or an optionally substituted aromatic groups, or R and R′ join to form an optionally substituted alicyclic compound, and wherein the product is formed with a selectivity of at least about 50%.
A composition comprising:
- a metal organic framework compound comprising a plurality of metal ions, each coordinated with at least one ligand;
- and
- a plurality of Co(CO)4− anions associated with at least a portion of the metal ions, wherein the at least one ligand comprises at least one carboxylate group.
A composition comprising:
- a metal organic framework (MOF) compound comprising a plurality of metal ions, each coordinated with at least one ligand;
- and
- a plurality of Co(CO)4− anions associated with at least a portion of the metal ions, wherein the MOF compound comprises Cr-MIL-101.
A method of synthesizing a composition, comprising:
- exposing a metal organic framework (MOF) comprising a plurality of metal ions, each coordinated with at least one ligand to a solution to disassociate a plurality of precursor anions from the metal organic framework and to associate a plurality of intermediary anions with the metal organic framework, wherein the plurality of precursor anions comprises F;
- and
- exposing the MOF to a solution comprising a plurality of Co(CO)4− anions, thereby forming a composition comprising the MOF having at least a portion of the metal ions associated with a Co(CO)4− anion.
A method of synthesizing a composition, comprising:
- exposing a metal organic framework (MOF) comprising a plurality of metal ions, each coordinated with at least one ligand to a solution to disassociate a plurality of precursor anions from the metal organic framework and to associate a plurality of intermediary anions with the metal organic framework, wherein the plurality of intermediary anions comprises Cl−;
- and
- exposing the MOF to a solution comprising a plurality of Co(CO)4− anions, thereby forming a composition comprising the MOF having at least a portion of the metal ions associated with a Co(CO)4− anion.
A method of synthesizing a composition, comprising:
- exposing a metal organic framework (MOF) comprising a plurality of metal ions, each coordinated with at least one ligand to a solution to disassociate a plurality of precursor anions from the metal organic framework and to associate a plurality of intermediary anions with the metal organic framework, wherein the solution comprises AlCl3;
- and
- exposing the MOF to a solution comprising a plurality of Co(CO)4− anions, thereby forming a composition comprising the MOF having at least a portion of the metal ions associated with a Co(CO)4− anion.
Dependencies are inferred from the claim text.