Methods of enhancing female fertility
AssigneePalo Alto Investors
InventorsAnthony Joonkyoo Yun, Conrad Minkyoo Yun, Kimberly A. Bazar
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Abstract
Methods of enhancing fertility of a female subject by increasing the number of oogonia present in the ovary of the female subject are provided. Aspects of the methods include methods of in vivo expansion of oogonia as well as methods of ex vivo expansion of oogonia.
Claims13
A method of enhancing the fertility of a female subject by in vivo expansion of oogonia, the method comprising increasing the number of oogonia present in the ovary of the female subject by locally introducing nucleic acids encoding a combination of-reprogramming factors to the ovary cells of the female subject in vivo via a vector, wherein the combination of reprogramming factors comprises Oct4, Sox2, Klf4, and c-Myc.
Dependencies are inferred from the claim text.