Back to results
US 11,174,257 B2Granted
Salts of an FGFR inhibitor
AssigneeIncyte Corporation
InventorsZhongjiang Jia, Jiacheng Zhou, Qun Li
Life of this patent
Estimating the term…
Abstract
The present invention relates to salt forms of the Fibroblast Growth Factor Receptors (FGFR) inhibitor 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3′,2′:5,6]pyrido[4,3-d]pyrimidin-2-one, including methods of preparation thereof, where the compound is useful in the treatment of FGFR mediated diseases such as cancer.
Claims13
A salt which is an acid salt of 3-(2,6-difluoro-3,5-dimethoxyphenyl) -1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3′, 2′:5,6]pyrido[4,3-d]pyrimidin-2-one, having the structure:
- or a hydrate or solvate thereof, wherein the acid is selected from L-(+)-tartaric acid and D-(−)-tartaric acid, wherein the salt is crystalline, and wherein:
- the salt is 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4, 7-tetrahydro-2H-pyrrolo[3′,2′:5,6]pyrido[4,3-d]pyrimidin-2-one L-(+)-tartrate having at least one characteristic X-ray powder diffraction peak selected from about 3.8, about 8.5, about 9.1, about 10.3, and about 12.0 degrees 2-theta;
- or
- the salt is 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4, 7-tetrahydro-2H-pyrrolo[3′,2′:5,6]pyrido[4,3-d]pyrimidin-2-one D-(−)-tartrate having at least one characteristic XRPD peaks selected from about 7.4, about 10.5, about 12.9, about 13.6, about 14.8, and about 16.4 degrees 2-theta.
1 more element
Dependencies are inferred from the claim text.