Azetidinimines as carbapenemases inhibitors

Compound of formula (I):

• wherein:
• R1 represents a chemical moiety chosen in the group consisting of hydrogen, cyano, C3-C10 cycloalkyl, C1-C10 alkoxy, C1-C10 haloalkoxy, (C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-haloalkoxy-(C1-C6)-alkyl, C1-C10 thioalkyl, (C1-C6)-alkylthio-(C1-C6)-alkyl, C1-C10 alkylsulfinyl, C1-C10 haloalkylsulfinyl, C1-C10 haloalkylsulfonyl, C3-C10 trialkylsilyl, C1-C10 alkylsulfonyl, C5-C12 arylsulfonyl, formyl, C2-C10 alkylcarbonyl, C2-C10 alkenyl, C2-C10 alkynyl, C2-C10 alkenyloxy, C2-C10 alkynyloxy, C2-C10 alkenylthio, C2-C10 alkynylthio, C1-C10 haloalkyl, C2-C10 haloalkenyl, C2-C10 haloalkynyl, C2-C10 haloalkylcarbonyl, C1-C10 haloalkylthio, C2-C10 haloalkenyloxy, C2-C10 haloalkynyloxy, C2-C10 haloalkenylthio, C2-C10 haloalkynylthio, (C5-C12)-aryl-(C1-C6)-alkyl, (C5-C12)-aryl-(C1-C6)-alkyl ester or a mono or polycyclic C5-C12 aryl or mono or polycyclic C3-C12 heteroaryl fragments,
• wherein the aryl or heteroaryl fragments are optionally substituted by
• one or several halogen atoms, hydroxyl (OH), nitro, cyano, formyl, C1-C6 alkyl, C3-C7 cycloalkyl, amino-C1-C10 alkoxy, (carboxylic acid)-C1-C10 alkoxy, (carboxylic (C1-C6)alkyl ester)-C1-C10 alkoxy, (1,2 diol)-C2-C10 alkoxy, —O—(C1-C6)alkyl-O—(C1-C6)alkyl-OH, (C1-C6)-alkoxy-(C1-C6)-alkyl, C2-C6 alkylcarbonyl, C1-C6 alkylthio, C1-C6 thioalkyl, (C1-C6)-alkylthio-(C1-C6)-alkyl, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 haloalkoxy alkyl, C2-C6 haloalkylcarbonyl, C1-C6 haloalkylthio, C1-C6 haloalkylsulfinyl, C1-C6 haloalkylsulfonyl, C3-C6 trialkylsilyl, C2-C6 alkenyl, C2-C6 alkynyl, C2-C6 haloalkynyl, C2-C6 haloalkenyl, C2-C6 haloalkenyloxy, C2-C6 haloalkynyloxy, C2-C6 alkenyloxy, C2-C6 alkynyloxy, C2-C6 alkenylthio, C2-C6 alkynylthio, C2-C6 haloalkenylthio, C2-C6 haloalkynylthio and/or a C1-C6 alkoxy optionally substituted by a mono or polycyclic C5-C12 aryl group, and/or
• a bridging group of formula —O—CH2—O— or —O—CH2CH2—O—;
• R2, R3, R4 and R5, independently one from each other, represent a chemical moiety chosen in the group consisting of hydrogen, halogen, nitro, cyano, C1-C10 alkyl, C3-C10 cycloalkyl, C1-C10 alkoxy, C1-C10 haloalkoxy, (C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-haloalkoxy-(C1-C6)-alkyl, C1-C10 thioalkyl, (C5-C12)-aryl-(C1-C6)-alkyl ester, (C1-C6)-alkylthio-(C1-C6)-alkyl, C1-C10 alkylsulfinyl, C1-C10 haloalkylsulfinyl, C1-C10 haloalkylsulfonyl, C3-C10 trialkylsilyl, C1-C10 alkylsulfonyl, C5-C12 arylsulfonyl, formyl, C2-C10 alkylcarbonyl, C2-C10 alkenyl, C2-C10 alkynyl, C2-C10 alkenyloxy, C2-C10 alkynyloxy, C2-C10 alkenylthio, C2-C10 alkynylthio, C1-C10 haloalkyl, C2-C10 haloalkenyl, C2-C10 haloalkynyl, C2-C10 haloalkylcarbonyl, C1-C10 haloalkylthio, C2-C10 haloalkenyloxy, C2-C10 haloalkynyloxy, C2-C10 haloalkenylthio, C2-C10 haloalkynylthio, (C5-C12)-aryl-(C1-C6)-alkyl or a mono or polycyclic C5-C12 aryl or mono or polycyclic C3-C12 heteroaryl fragments, wherein the aryl or heteroaryl fragments are optionally substituted by one or several halogen atoms, nitro, cyano, formyl, COOH, —COO(C1-C6 alkyl), C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 N3-substituted alkyl, C1-C6 NH2-substituted alkyl, C1-C6 alcohol, C1-C6 alkoxy, (C1-C6)-alkoxy-(C1-C6)-alkyl, C2-C6 alkylcarbonyl, C1-C6 alkylthio, C1-C6 thioalkyl, (C1-C6)-alkylthio-(C1-C6)-alkyl, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 haloalkoxy alkyl, C2-C6 haloalkylcarbonyl, C1-C6 haloalkylthio, C1-C6 haloalkylsulfinyl, C1-C6 haloalkylsulfonyl, C3-C6 trialkylsilyl, C2-C6 alkenyl, C2-C6 alkynyl, C2-C6 haloalkynyl, C2-C6 haloalkenyl, C2-C6 haloalkenyloxy, C2-C6 haloalkynyloxy, C2-C6 alkenyloxy, C2-C6 alkynyloxy, C2-C6 alkenylthio, C2-C6 alkynylthio, C2-C6 haloalkenylthio, C2-C6 haloalkynylthio, a monocyclic C5-C6 aryl group optionally substituted by a C1-C6 alkyloxy group and/or a COO(C1-C6 alkyl) group wherein the alkyl is substituted by NH2 or NHCOO(C1-C6)alkyl or NHCOO(C1-C6)alkyl(mono or polycyclic C5-C12)aryl;
• R6 represents a mono or polycyclic C5-C12 aryl fragment, wherein the aryl fragment is optionally substituted by one or several halogen atoms, cyano, formyl, nitro, C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 alkoxy, (C1-C6)-alkoxy-(C1-C6)-alkyl, C2-C6 alkylcarbonyl, C1-C6 alkylthio, C1-C6 thioalkyl, (C1-C6)-alkylthio-(C1-C6)-alkyl, C1-C6alkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 haloalkoxy alkyl, C2-C6 haloalkylcarbonyl, C1-C6 haloalkylthio, C1-C6 haloalkylsulfinyl, C1-C6 haloalkylsulfonyl, C3-C6 trialkylsilyl, C2-C6 alkenyl, C2-C6 alkynyl, C2-C6 haloalkynyl, C2-C6 haloalkenyl, C2-C6 haloalkenyloxy, C2-C6 haloalkynyloxy, C2-C6 alkenyloxy, C2-C6 alkynyloxy, C2-C6 alkenylthio, C2-C6 alkynylthio, C2-C6 haloalkenylthio, C2-C6 haloalkynylthio fragments, and/or a monocyclic C5-C6 aryl group optionally substituted by a C1-C6 alkyloxy group;
• or a solvate or a salt thereof;
• provided that at least two of R3, R4 and R5 represent a hydrogen atom and R2 or R3 is different from hydrogen.