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US 11,173,217 B2Granted
Methods and compositions for near infrared fluorescent nanodots with aggregation-induced emission characteristics
AssigneeNational University of Singapore
InventorsBin Liu, Jie Liu
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Abstract
Disclosed herein is a donor-acceptor-donor (D-A-D) compound of formula I, where in the acceptors are mono-substituted tetraphenylethylene moieties. Also disclosed herein are fluorescent nanodots that comprise the compound of formula (I) and uses of said compound or nanodots in in vivo imaging or detecting of cancer cells in a subject.
Claims14
A compound of structural formula I:
- wherein,
- X represents an acceptor moiety selected from the group consisting of:
- where each wavy line represents a point of attachment to the rest of the compound, and R7 represents C1-21 alkyl;
- R1 and R2 independently represent OR5 or C1-21 alkyl;
- R3 and R4 independently represent OR6 or C1-21 alkyl;
- R5 and R6 independently represent C1-21 alkyl;
- m and n represent 0 or 1;
- and
- o and p represent 0 or 1, provided that:
- when m and n represent 0, o and p represent 1;
- and
- when o and p represent 0, m and n represent 1.
9 more elements
Dependencies are inferred from the claim text.