Anti-RNA virus composition comprising EPRS protein or fragment thereof
AssigneesKorea Research Institute of Bioscience and Biotechnology, Medicinal Bioconvergence Research Center
InventorsMyung Hee Kim, Eun Young Lee, Sung Hoon Kim, Chul Ho Lee
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Abstract
The present invention relates to an EPRS (glutamyl-prolyl-tRNA synthetase) protein or a fragment thereof. The EPRS protein of the present invention or fragment thereof may bind to PCBP2 protein to activate the MAVS signaling pathway, and thus it has anti-RNA viral effects, thereby being effective for preventing or treating a RNA viral infectious disease.
Claims19
A method of treating an RNA viral infectious disease in a subject in need thereof, comprising administering to the subject in need thereof a fragment of an EPRS (glutamyl-prolyl-tRNA synthetase) protein that is optionally bound to a drug delivery vehicle, wherein the fragment of the EPRS protein consists of an amino acid sequence selected from the group consisting of the amino acid sequence at positions 166 to 506, the amino acid sequence at positions 168 to 506, the amino acid sequence at positions 166 to 269, the amino acid sequence at positions 168 to 269, the amino acid sequence at positions 166 to 196, the amino acid sequence at positions 168 to 196, the amino acid sequence at positions 166 to 186, and the amino acid sequence at positions 168 to 186 in SEQ ID NO:
- 63.
A method of inhibiting MAVS protein degradation in a subject in need thereof, comprising administering to the subject in need thereof a fragment of an EPRS (glutamyl-proplyl-tRNA synthetase) protein, wherein the fragment of the EPRS protein consists of an amino acid sequence selected from the group consisting of the amino acid sequence at positions 166 to 506, the amino acid sequence at positions 168 to 506, the amino acid sequence at positions 166 to 269, the amino acid sequence at positions 168 to 269, the amino acid sequence at positions 166 to 196, the amino acid sequence at positions 168 to 196, the amino acid sequence at positions 166 to 186, and the amino acid sequence at positions 168 to 186 in SEQ ID NO:
- 63.
A fragment of an EPRS protein bound to a drug delivery vehicle, wherein the fragment of the EPRS protein consists of an amino acid sequence selected from the group consisting of the amino acid sequence at positions 166 to 506, the amino acid sequence at positions 168 to 506, the amino acid sequence at positions 166 to 269, the amino acid sequence at positions 168 to 269, the amino acid sequence at positions 166 to 196, the amino acid sequence at positions 168 to 196, the amino acid sequence at positions 166 to 186, and the amino acid sequence at positions 168 to 186 in SEQ ID NO:
- 63.
Dependencies are inferred from the claim text.