Altering the immundominance hierarchy using a DNA vaccine expressing conserved regions
AssigneesThe United States of America, as represented by the Secretary, Department of Health and Human Services, University of Washington through its Center for Commercialization
InventorsGeorge Pavlakis, Barbara Felber, James Mullins
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Abstract
The invention provides methods and compositions for eliciting broad immune responses. The methods employ nucleic acid vaccines that encodes highly conserved elements from a virus.
Claims19
A nucleic acid comprising a nucleotide sequence encoding a fusion polypeptide comprising the conserved element amino acid sequences of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, and SEQ ID NO:7, wherein the conserved elements are separated by alanine-containing peptide linker amino acid sequences.
Dependencies are inferred from the claim text.