Isotopically modified components and therapeutic uses thereof
AssigneeRetrotope, Inc.
InventorMikhail Sergeevich Shchepinov
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Abstract
Methods are provided of identifying a subject having impaired aldehyde dehydrogenase activity; and administering to the subject a compound comprising an isotopically-modified polyunsaturated fatty acid, an isotopically-modified polyunsaturated fatty acid ester, an isotopically-modified polyunsaturated fatty acid thioester, an isotopically-modified polyunsaturated fatty acid amide, a polyunsaturated fatty acid mimetic, or an isotopically-modified polyunsaturated fatty acid pro-drug, the compound having an isotopic modification that reduces oxidation of the compound, thereby reducing production in the subject of substrate for aldehyde dehydrogenase. Some aspects provide coadministering an isotopically-modified polyunsaturated fatty acid and an oxylipin.
Claims27
A method of treating, inhibiting the progression of, or ameliorating Alzheimer's disease in a patient diagnosed with impaired aldehyde dehydrogenase-2 activity, comprising:
- administering to the subject patient an effective amount of a compound comprising a polyunsaturated fatty acid, a polyunsaturated fatty acid ester, a polyunsaturated fatty acid thioester, or a polyunsaturated fatty acid amide,
- wherein the polyunsaturated fatty acid, the polyunsaturated fatty acid ester, the polyunsaturated fatty acid thioester, or the polyunsaturated fatty acid amide is deuterated at one or more bis-allylic positions.
Dependencies are inferred from the claim text.