Methionine-producing yeast

A methionine-producing and/or methionine derivatives-producing recombinant yeast, in the genome of which:

• (A) at least one nucleic acid encoding an aspartate semi-aldehyde dehydrogenase and/or at least one nucleic acid encoding an aspartate semi-aldehyde dehydrogenase that can use as coenzyme both NAD and NADP is overexpressed or is under the control of an inducible or repressible promoter;
• (B) at least one nucleic acid encoding an aspartokinase is under the control of an inducible or repressible promoter;
• and
• (C) (i) a) at least one nucleic acid encoding an homoserine-O-acetyltransferase MET2 is overexpressed or is under the control of an inducible or repressible promoter;
• and/or at least one nucleic acid encoding an homoserine-O-acetyltransferase METX is overexpressed or is under the control of an inducible or repressible promoter, and
• b) at least one nucleic acid encoding a methionine synthase is overexpressed or is under the control of an inducible or repressible promoter;
• and/or
• ii) a) at least one nucleic acid encoding an homoserine kinase is overexpressed or is under the control of an inducible or repressible promoter, and
• b) at least one nucleic acid encoding a cystathionine gamma-synthase 1 that has an improved O-phospho-L-homoserine (OHPS) dependent methionine synthase activity is overexpressed or is under the control of an inducible or repressible promoter,
• wherein the yeast is selected from the species Saccharomyces cerevisiae, Saccharomyces boulardii, Saccharomyces douglasii, Saccharomyces bayanus, Zigosaccharomyces bailii, Dekkera brucelensis, Dekkera intermedia, Kluyveromyces themotolerens, Torulaspora globose and Torulaspora glabrata.