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AssigneeJiangsu Academy of Agricultural Sciences
InventorsXianjin Liu, Yajing Xie, Chongxin Xu, Xiao Zhang, Meijing Gao, Xin He, Yuan Liu, Cunzheng Zhang
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The present invention provides a human-derived molecularly modified insecticidal protein, and a preparation method and application thereof, and belongs to the field of genetic engineering and biological control. The present invention provides a human-derived molecularly modified insecticidal protein, and the amino acid sequence of the insecticidal protein CCL-CCL_scFv is shown as SEQ ID No. 1. The insecticidal protein CCL-CCL_scFv shows significantly higher affinity with midgut BBMV of Plutella xylostella than Cry1Ab toxin, competes with Cry1Ab and Cry1Ac toxins for binding the midgut BBMV of Plutella xylostella, and is a mimic of Cry1Ab and Cry1Ac toxins. Through Plutella xylostella indoor insecticidal biological activity assay, the insecticidal protein shows a good insecticidal effect, and can effectively replace Cry1Ac or Cry1Ab toxin for biological control of insect pest.
A human-derived molecularly modified insecticidal protein, wherein the amino acid sequence of the human-derived molecularly modified insecticidal protein is shown as SEQ ID No. 1.
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