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US 11,161,826 B2Granted
Manufacturing methods and polymorphs of a thiazoline anti-hyperalgesic agent
AssigneeACADIA Pharmaceuticals Inc.
InventorScott L. Dax
Life of this patent
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Abstract
Provided herein are methods of making a thiazoline anti-hyperalgesic, Compound 1, and polymorphs thereof. The methods described herein use inexpensive reagents and are capable of providing Compound 1 in commercial-scale quantities. Also provided are pharmaceutical compositions of Compound 1 suitable for human administration.
Claims6
A composition comprising a compound of Formula I:
- wherein the composition comprises about 0.0001% to about 0.004% w/w, relative to the weight of Compound 1 in the composition, of each of:
- 2-Cl-BO (2-Chlorobenzoxazole),
- BO-Imp-3 (2-Aminophenol), and
- BO-Imp-4 (2-[Bis(1,3-benzoxazol-2-yl) amino]phenol).
1 more element
A crystalline form of the compound of Formula I:
- wherein the crystalline form is characterized by an X-ray powder diffraction (XPRD) pattern comprising approximate peak positions (degrees 2θ±0.2), when measured using Cu Kα radiation, of 9.6, 15.2, 18.0, 19.4, 23.0, and 31.4, when the XPRD is collected from about 2 to about 42 degrees 2θ.
Dependencies are inferred from the claim text.