Amide compounds and use thereof
AssigneeNeoPharm, Inc.
InventorsKyung Sook Yoo, Bu-Mahn Park, Min Hee Kim, Yu Ra Jung, Hye Seong Shin
Life of this patent
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Abstract
Provided are a novel amide compound and a use thereof. According to the present invention, there may be provided a use of a novel amide compound which is harmless to the human body with excellent skin stability and decreases activity of peroxisome proliferator activated receptor gamma (PPAR-γ) to fundamentally inhibit sebum overproduction, thereby providing the skin with an effective effect, and a cosmetic composition including the same.
Claims8
An amide compound represented by the following Chemical Formula 1, a pharmaceutically acceptable salt thereof, or a solvate thereof:
- wherein
- R1 and R2 are independently of each other (C1-C6) alkyl;
- one selected from R3 and R4 is (C1-C30) alkyl, and the other one is hydrogen;
- R5 is hydrogen or (C1-C30)alkyl;
- and
- the alkyl of R3 or R4 may be further substituted by one or more substituents selected from (C1-C30) alkylthio;
- and amino, guanidino, —(C═O)NH2, —(C═O)OR, (C3-C30) heteroaryl, and salts thereof, in which R is hydrogen or (C1-C30) alkyl, and the heteroaryl contains N.
A method for decreasing activity of PPAR-γ by applying a compound represented by Chemical Formula 1 as an effective component on skin:
- wherein
- R1 and R2 are independently of each other (C1-C30) alkyl;
- one selected from R3 and R4 is (C1-C30) alkyl, and the other one is hydrogen or (C1-C30) alkyl;
- R5 is hydrogen or (C1-C30)alkyl;
- and
- the alkyl of R3 and R4 may be further substituted by one or more substituents selected from hydroxy;
- (C1-C30) alkoxy;
- (C1-C30) alkylthio;
- and amino, guanidino, —(C═O)NH2, —(C═O)OR, (C3-C30) heteroaryl, and salts thereof, in which R is hydrogen or (C1-C30) alkyl, and the heteroaryl contains N.
Dependencies are inferred from the claim text.