Process for the preparation of Eltrombopag olamine and its intermediates
AssigneeAurobindo Pharma Ltd
InventorsMoturu Venkata Ramakrishna Murthy, Tiwari Shashi Kant, Nadakudity Sailendra Kumar, Samala Bhanuchander, Rajesh Chennuri, Srinivasa Chary Katuroju, Sivakumaran Meenakshisunderam
Life of this patent
Estimating the term…
Abstract
The present invention relates to an improved process for the purification of Eltrombopag olamine of compound of formula (2). The present invention also relates to an improved process for the preparation of Eltrombopag olamine intermediates and further conversion to Eltrombopag olamine of a compound of formula (2).
Claims4
A process for the purification of Eltrombopag olamine salt of a Compound of Formula (2);
- which process comprises the steps of:
- (i) providing a solution of Eltrombopag olamine salt of a Compound of Formula (2) in a suitable solvent;
- (ii) optionally, filtering the resulting solution;
- (iii) adding an anti-solvent to the resulting solution;
- and
- (iv) isolating the pure Eltrombopag olamine salt of a Compound of Formula (2).
A process for the purification of Eltrombopag olamine salt of a Compound of Formula (2):
- which comprises:
- (i) providing a solution of Eltrombopag olamine salt of a Compound of Formula (2) in Dimethyl sulfoxide (DMSO) solvent;
- (ii) optionally, filtering the resulting solution;
- (iii) adding ethanol as an anti-solvent to the resulting solution;
- and
- (iv) isolating the pure Eltrombopag olamine salt of a Compound of Formula (2).
Dependencies are inferred from the claim text.