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US 11,161,802 B2Granted
L-ornithine phenyl acetate and methods of making thereof
AssigneeOcera Therapeutics, Inc.
InventorsKeith Anderson, Jim Behling, Christine Henderson Dougan, Stephen William Watt, Peter Manini, Attilia Figini
Life of this patent
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Abstract
Disclosed herein are forms of L-ornithine phenyl acetate and methods of making the same. A crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate.
Claims15
A process for preparing L-ornithine phenylacetate, comprising
- intermixing phenylacetic acid or a salt thereof with an L-ornithine acetate solution to form a reaction mixture;
- and
- isolating a composition comprising a crystalline form of L-ornithine phenylacetate from the reaction mixture.
Dependencies are inferred from the claim text.