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US 11,160,795 B2Granted
Methods of treating tuberous sclerosis complex with cannabidiol and everolimus
AssigneeGW Research Limited
InventorsGeoffrey Guy, Volker Knappertz, Eduardo Dunayevich, David Critchley
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Abstract
The present disclosure provides methods of treating tuberous sclerosis complex comprising administering cannabidiol and everolimus.
Claims29
A method of treating seizures in a human suffering from tuberous sclerosis complex comprising:
- (a) co-administering therapeutically effective amounts of everolimus and cannabidiol to the human suffering from a tuberous sclerosis complex;
- (b) monitoring the blood plasma concentrations of everolimus in the human suffering from the tuberous sclerosis complex;
- (c) if the human suffering from the tuberous sclerosis complex's blood plasma trough concentrations of everolimus exceed 15 ng/mL, if the Cmax exceeds 50 ng/mL, or if the AUC 0-24 exceeds 500 h*ng/mL;
- then
- (d) reducing the everolimus administered in step (a) to the human suffering from the tuberous sclerosis complex by at least 10%;
- wherein said monitoring in step (b) occurs one week to two weeks after the human suffering from the tuberous sclerosis complex begins receiving everolimus, and wherein the cannabidiol is synthetic or purified.
3 more elements
Dependencies are inferred from the claim text.