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US 11,160,770 B2Granted
Compounds, compositions and methods for treating oxidative DNA damage disorders
AssigneeIndiana University Research and Technology Corporation
InventorsMark R. Kelley, Michael R. Vasko
Life of this patent
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Abstract
Compounds, compositions, and formulations, and accompanying methods useful for treating disorders arising from oxidative DNA damage, including oxidative DNA damage resulting from ionizing radiation or other therapy are described herein.
Claims19
A compound for preventing or treating neuronal damage in a host animal, the compound having the formula
- or a pharmaceutically acceptable salt thereof, wherein:
- RA represents a fused aryl ring that is optionally substituted;
- R is alkoxy, heteroalkoxy, cycloalkoxy, or cycloheteroalkoxy, each of which is optionally substituted;
- X is alkylene, alkenylene, or alkynylene, each of which is optionally substituted;
- and
- Y is N(R1)2 or NR2OR2, wherein each R1 is independently selected from the group consisting of alkyl, heteroalkyl, cycloalkyl, and cycloheteroalkyl, each of which is optionally substituted, or both R1 are taken together with the attached nitrogen to form an optionally substituted heterocycle;
- wherein each R2 is independently selected from the group consisting of a prodrug group, hydrogen, alkyl, alkyl heteroalkyl, cycloalkyl, and cycloheteroalkyl, each of which is optionally substituted.
4 more elements
A compound for preventing or treating neuronal damage in a host animal, the compound having the formula
- or a pharmaceutically acceptable salt thereof, wherein:
- RA represents a fused aryl ring that is optionally substituted;
- R is alkoxy, heteroalkoxy, cycloalkoxy, or cycloheteroalkoxy, each of which is optionally substituted;
- X is a alkylene, alkenylene, or alkynylene, each of which is C3-C9 alkyl substituted;
- and
- Y is a carboxylic acid or ester.
3 more elements
Dependencies are inferred from the claim text.