Silicone foam compositions rapidly cross-linkable at ambient temperatures and methods of making and using same
AssigneeEthicon, Inc.
InventorsDuan Li Ou, Leo B. Kriksunov
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Abstract
Provided are rapidly cross-linkable silicone foam compositions, kits, and methods for filling implanted medical devices in situ or in vivo, the implanted medical devices, including for example, body implants and tissue expanders, the compositions including a platinum divinyl disiloxane complex; a low viscosity vinyl terminated polydimethylsiloxane; a low viscosity hydride terminated polydimethylsiloxane; a silicone cross-linker; and a gas and/or gas-filled microcapsules, where the rapidly cross-linkable silicone foam composition has a viscosity of ≤150 cPs for ≥1 min. post-preparation and ≤300 cPs≤5 min. post-preparation, at ambient temperature.
Claims29
A two-part, rapidly cross-linkable silicone foam composition, comprising:
- a catalyst fluid comprising
- a first low viscosity vinyl terminated polydimethylsiloxane present in an amount of from about 97 wt % to about 99.5 wt % based on the weight of the catalyst fluid and having a viscosity of from about 1 to about 150 cPs, and
- a platinum divinyl disiloxane complex comprising Pt[(CH2═CH)(CH3)2SiOSi(CH3)2(CH═CH2)]3 having a platinum content of from about 2 ppm to about 32 ppm based on the catalyst fluid,
- wherein the catalyst fluid has a viscosity of from about 1 to about 150;
- and
- a cross-linker suspension comprising
- a second low viscosity vinyl terminated polydimethylsiloxane present in an amount of from about 1 wt % to about 40 wt % based on the weight of the cross-linker suspension and having a viscosity of from about 1 to about 150 cPs,
- a low viscosity hydride terminated polydimethylsiloxane present in an amount of from about 60 wt % to about 90 wt % based on the weight of the cross-linker suspension and having a viscosity of from about 1 to about 150 cPs,
- a silicone cross-linker comprising polymethylhydrosiloxane polydimethylsiloxane copolymer present in an amount of from about 0.32 wt % to about 5.0 wt % based on the weight of the cross-linker suspension, and having a viscosity of from about 1 to about 150 cPs, and
- a sterile gas or a population of gas-filled microcapsules,
- wherein the cross-linker suspension has a viscosity of from about 1 to about 150 cPs, and
- wherein, post-preparation, the resultant rapidly cross-linkable silicone foam composition has a viscosity of ≤150 cPs for ≥1 min. post-preparation and ≤300 cPs≤5 min. post-preparation, at ambient temperature, and the resultant rapidly cross-linkable silicone foam composition has a platinum content of from about 1 ppm to about 16 ppm.
A two-part, rapidly cross-linkable silicone foam composition, comprising:
- a catalyst fluid comprising
- a first low viscosity vinyl terminated polydimethylsiloxane, and
- a platinum divinyl disiloxane;
- and
- a cross-linker suspension comprising
- a second low viscosity vinyl terminated polydimethylsiloxane,
- a low viscosity hydride terminated polydimethylsiloxane,
- a silicone cross-linker, and
- a sterile gas or a population of gas-filled microcapsules,
- wherein, post-preparation, a resultant composition has a viscosity of ≤150 cPs for ≥1 min. post-preparation at ambient temperature.
Dependencies are inferred from the claim text.