Methods for identifying a companion animal susceptible to treatment that reduces the risk of stone formation and compositions for reducing such risk

A method of reducing risk of calcium oxalate stone formation in a feline subject comprising the steps of:

• identifying the feline subject as being a feline subject that would benefit from a treatment that reduces risk of calcium oxalate stone formation;
• and
• administering to the feline subject a composition that comprises effective amounts of betaine, green tea, fenugreek and tulsi
• wherein the composition comprises 0.1 to 1.0% betaine, 0.05 to 0.50% green tea, 0.005% to 0.1% fenugreek, and 0.0001 to 0.005% tulsi.

A method of identifying a feline subject that would benefit from a treatment that reduces risk of calcium oxalate stone formation, wherein the treatment that reduces risk of calcium oxalate stone formation comprises administering to the feline subject a composition that comprises an effective amount of betaine, green tea, fenugreek and tulsi, wherein the composition comprises 0.1 to 1.0% betaine, 0.05 to 0.50% green tea, 0.005% to 0.1% fenugreek, and 0.0001 to 0.005% tulsi;

• the method comprises:
• analyzing a biological sample obtained from the feline subject to determine the feline subject's betaine concentration and/or 2-oxoarginine concentration;
• and
• comparing the feline subject's betaine concentration and/or 2-oxoarginine concentration with a positive reference standard for betaine concentration and/or 2-oxoarginine concentration that is representative of betaine concentration and/or 2-oxoarginine concentration of a cat that would benefit from the treatment and/or results from analyzing a positive control sample containing betaine and/or 2-oxoarginine in concentration that is representative of betaine concentration and/or 2-oxoarginine concentration of a cat that would benefit from the treatment,
• wherein the feline subject's betaine concentration being equal to or less than the positive reference betaine concentration value and/or betaine concentration in the positive control sample containing beta-amino isobutyrate and/or the feline subject's 2-oxoarginine concentration being equal to or greater than the positive reference 2-oxoarginine concentration value and/or 2-oxoarginine concentration in the positive control sample containing 2-oxoarginine concentration indicates that the feline subject would benefit from a treatment.