Antiviral peptide and use thereof
AssigneesToagosei Co., Ltd., National University Corporation Hokkaido University
InventorsTetsuhiko Yoshida, Ayato Takada, Nahoko Baileykobayashi
Life of this patent
Estimating the term…
Abstract
An antiviral peptide provided according to the present invention includes (1) an amino acid sequence (TM sequence) constituting a transmembrane region of G protein of vesicular stomatitis virus (VSV) or a modified amino acid sequence formed by conservative substitutions of 1, 2, or 3 amino acid residues in the TM sequence; and (2) an amino acid sequence (CPP sequence) functioning as a cell penetrating peptide (CPP), wherein a total number of amino acid residues is 100 or less.
Claims13
A synthetic peptide inhibiting proliferation of at least one type of virus, the synthetic peptide comprising,
- (1) an amino acid sequence represented by any one of SEQ ID NOs:
- 1 to 3;
- and
- (2) a cell penetrating peptide (CPP) sequence being a polyarginine or an amino acid sequence represented by any one of SEQ ID NOs:
- 4 to 21,
- wherein the number of amino acid residues of the above (1) amino acid sequence and (2) CPP sequence in combination is 80% or more of the total number of amino acid residues of the synthetic peptide.
An antiviral composition inhibiting proliferation of at least one type of virus, the antiviral composition comprising:
- a synthetic peptide;
- and
- at least one pharmaceutically acceptable carrier,
- wherein the synthetic peptide comprises
- (1) an amino acid sequence represented by any one of SEQ ID NOs:
- 1 to 3;
- and
- (2) a cell penetrating peptide (CPP) sequence being a polyarginine or an amino acid sequence represented by any one of SEQ ID NOs:
- 4 to 21, and the number of amino acid residues of the above (1) amino acid sequence and (2) CPP sequence in combination is 80% or more of the total number of amino acid residues of the synthetic peptide.
A method of inhibiting proliferation of at least one type of virus, the method comprising:
- supplying a synthetic peptide to a subject at least once, wherein the synthetic peptide comprises:
- (1) an amino acid sequence represented by any one of SEQ ID NOs:
- 1 to 3;
- and
- (2) a cell penetrating peptide (CPP) sequence being a polyarginine or an amino acid sequence represented by any one of SEQ ID NOs:
- 4 to 21,
- wherein the number of amino acid residues of the above (1) amino acid sequence and (2) CPP sequence in combination is 80% or more of the total number of amino acid residues of the synthetic peptide.
Dependencies are inferred from the claim text.