US 11,149,043 B2Granted

Prodrug modulators of the integrated stress pathway

AssigneesCalico Life Sciences LLC, AbbVie Inc.

InventorsMichael J. Dart, Jennifer M. Frost, Yunsong Tong, Xiangdong Xu, Lei Shi, Kathleen Murauski, Marina Pliushchev, Brian S. Brown, Eric Voight, John T. Randolph

Life of this patent

Estimating the term…

Abstract

Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

Claims2

Dependent claims

A compound, wherein the compound is

or a pharmaceutically acceptable salt thereof.

Dependencies are inferred from the claim text.

Facts

Application: 17/227,071Filed 9 Apr 2021 · continuation
Priority: 11 Oct 2018
Published: US 2021/0230195 A129 Jul 2021
Granted: 19 Oct 2021
Term ends: Not estimatedThe source records don’t support an estimate.

Classification11 codes

C07C 235/36
The carbon skeleton containing six-membered aromatic rings: having the nitrogen atom of at least one of the carboxamide groups bound to a carbon…
C07F 9/12
Esters of phosphoric acids: with hydroxyaryl compounds
C07C 271/34
Having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings: with the nitrogen atoms of the…
C07C 303/34
Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides: of amides of…

Family

Application62/744,293Us provisional application · filed 11 Oct 2018
PCT/US2019/055850Parent of this continuation · filed 11 Oct 2019
US 2021/0230195 A1Pre-grant publication · published 29 Jul 2021
US 11,149,043 B2This patent

From the US filing history. Foreign family members aren’t listed.

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