Bioresorbable scaffold having sustained drug delivery
OwnerJohn James Scanlon, Catherine Ann Scanloninventors
Life of this patent
Estimating the term…
Abstract
A multilayer bioresorbable stent having sustained drug delivery is disclosed herein. The bioresorbable stent releases a therapeutic substance from the body of the bioresorbable stent starting when the bioresorbable stent is implanted within an anatomical lumen and ending when the entire mass of the bioresorbable stent is no longer present within the anatomical lumen. The bioresorbable stent releases the therapeutic substance gradually during the treatment as the mass of the each layer of the bioresorbable stent erodes. Methods of making the therapeutic layers within the bioresorbable sent are further disclosed. Sustained drug delivery reduces the risk of late and very late stent thrombosis.
Claims29
A method of making a bioresorbable, implantable device comprising:
- providing one film comprising at least one bioresorbable material, a film width, a film length, two major surfaces, four minor surfaces and a film thickness,
- covering at least one part of at least one major surface of the film with at least one active ingredient in a way that leaves at least one different part of the same major surface uncovered with the active ingredient so that the film has at least one dry active-ingredient-storage-area and at least one dry active-ingredient-free-area on the same major surface, and
- forming the film with the dry active-ingredient-storage-area into the configuration of a cylindrical-shaped roll comprising a roll outer diameter, a roll inner diameter, a roll length, a roll central axis, a roll passageway and a roll thickness comprising multiple film thicknesses wrapped around said roll central axis.
A method of making a bioresorbable, implantable device comprising:
- providing one film comprising a film width, a film length, two major surfaces, four minor surfaces and a film thickness comprising at least one bioresorbable material and no active ingredient within at least one part of the film length to form at least one active-ingredient-free-area and comprising at least one bioresorbable material and at least one active ingredient within at least one different part of the film length to form at least one active-Ingredient-storage-area, and
- forming the film with the active-ingredient-storage-area into the configuration of a cylindrical-shaped roll comprising a roll outer diameter, a roll inner diameter, a roll length, a roll central axis, a roll passageway and a roll thickness comprising multiple film thicknesses wrapped around said roll central axis.
A method of making a bioresorbable, implantable device comprising:
- providing at least one film comprising at least one bioresorbable material, a film width, a film length, two major surfaces, four minor surfaces and a film thickness and providing at least one additional film comprising at least one bioresorbable material and at least one active ingredient, an additional film width, an additional film length, two additional major surfaces, four additional minor surfaces and an additional film thickness,
- organizing the one film and at least one additional film in an arrangement, and
- forming the arrangement of the one film and at least one additional film into the configuration of a cylindrical-shaped roll comprising a roll outer diameter, a roll inner diameter, a roll length, a roll central axis, a roll passageway and a roll thickness comprising multiple film thicknesses wrapped around said roll central axis.
Dependencies are inferred from the claim text.