System and method for serum based cancer detection

A system comprising:

• an illumination source configured to illuminate a location of a biological sample that is a body fluid droplet that has not been treated with a solution or a reagent to generate a plurality of interacted photons;
• a mirror configured to direct a first portion of the plurality of interacted photons;
• a fiber array spectral translator device comprising a two dimensional array of optical fibers drawn into a one dimensional fiber stack, the fiber array spectral translator device configured to receive the first portion of the plurality of interacted photons at the two-dimensional array of fibers and convert the first portion of the plurality of interacted photons into a linear arrangement;
• a spectrometer configured to optically receive the linear arrangement of the first portion of the plurality of interacted photons from the fiber array spectral translator device and filter the first portion of the plurality of interacted photons into a plurality of filtered photons comprising a plurality of wavelengths;
• a detector configured to detect the plurality of filtered photons and generate a Raman data set;
• and
• a processor configured to analyze the Raman data set by sampling along an outer ring of the biological sample that is between the center of the biological sample and the periphery of the biological sample that is a body fluid droplet to identify a disease state.

A non-transitory storage medium containing machine readable program code, which, when executed by a processor, causes the processor to:

• cause an illumination source to illuminate a location of a biological sample that is a body fluid droplet that has not been treated with a solution or a reagent to generate a plurality of interacted photons;
• cause a collection device to collect the plurality of interacted photons and generate a plurality of collected photons;
• cause a fiber array spectral translator device to receive the plurality of collected photons at a two dimensional array of optical fibers and convert the plurality of collected photons into a linear arrangement at a one-dimensional fiber stack;
• cause a detector to detect the linear arrangement of the plurality of collected photons and generate a Raman data set;
• and
• analyze the Raman data set to identify a disease state,
• wherein the analyzing of the Raman data set is performed by sampling along an outer ring of the biological sample that is between the center of the biological sample and the periphery of the biological sample.