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US 11,143,662 B2Granted
Circulating biomarker levels for diagnosis and risk-stratification of traumatic brain injury
AssigneeBrainbox Solutions, Inc.
InventorsDonna J. Edmonds, Timothy E. Van Meter, NaZanin Mirshahi
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Abstract
Methods, compositions and kits useful in the diagnosis, prognosis and/or assessment of brain injuries and risk for brain injuries, such as hemorrhage, are based upon detection of certain biomarkers.
Claims8
A method of measuring the levels of biomarker proteins in a biological sample from a human patient that has or is suspected of having a brain injury, the method comprising:
- (a) measuring levels of the biomarker proteins Neuron Specific Enolase (NSE) and Synuclein Beta (SNCB) in the biological sample;
- (b) detecting a changed level of NSE and a changed level of SNCB relative to reference levels of NSE and SNCB;
- and
- (c) administering treatment for a brain injury when an increased level of NSE and a decreased level of SNCB is detected.
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