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US 11,143,656 B2Granted
Diagnostic evaluation of antibody responses to commonly recognized prostate cancer-associated antigens
AssigneeWisconsin Alumni Research Foundation
InventorsDouglas G. McNeel, Brett B. Maricque
Life of this patent
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Abstract
The present invention relates to a plurality of antigens that together form a panel of immunoreactive molecules suitable for identifying candidates for prostate cancer examination. Methods for identifying antibodies indicative of a pre-malignant or malignant prostate are disclosed. Further disclosed are kits that can be used to practice the above methods.
Claims5
A method of identifying a human with prostate cancer, prostatitis or at risk of developing prostate cancer comprising the steps of:
- (a) contacting a serum sample obtained from the human with a panel comprising antigens encoded by SEQ ID NO:5, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:24, SEQ ID NO:25, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:35, SEQ ID NO:40, SEQ ID NO:44, SEQ ID NO:64, SEQ ID NO:68, SEQ ID NO:72, SEQ ID NO:76, SEQ ID NO:78, SEQ ID NO:80, SEQ ID NO:86, and SEQ ID NO:91, the encoded antigens being immobilized on one of a membrane, a plate, and a filter, and having a positive likelihood ratio of at least 4, wherein the sample comprises at least one antibody;
- and
- (b) identifying the human with prostate cancer, prostatitis or at risk of developing prostate cancer if at least one immunocomplex forms between the at least one antibody and at least one antigen of the panel.
Dependencies are inferred from the claim text.