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US 11,142,800 B2Granted
Biomarkers of cancer
AssigneeThe General Hospital Corporation
InventorsDavid Tsai Ting, Daniel A. Haber, Shyamala Maheswaran, Doron Lipson
Life of this patent
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Abstract
Methods for diagnosing cancer based on detecting the presence of increased levels of expression of satellite repeats and/or Line-1.
Claims11
An in vitro method of detecting a solid tumor of epithelial origin in a subject, the method comprising:
- quantifying a level of total HSATII satellite transcripts per million transcripts in a test sample comprising cells from the subject to obtain a test value;
- quantifying a level of total HSATII satellite transcripts per million transcripts in a noncancerous reference sample comprising cells of the same cell type as the test sample;
- detecting an increase in the test value compared to the level of total HSATII satellite transcripts per million transcripts in the noncancerous reference sample, wherein the increase indicates that the subject has cancer;
- and administering to the subject a surgical intervention, chemotherapy, radiation therapy, or a combination thereof.
1 more element
An in vitro method of detecting pancreatic cancer in a subject, the method comprising:
- quantifying a level of total HSATII satellite transcripts per million transcripts in a test sample comprising pancreatic cells from the subject to obtain a test value;
- quantifying a level of total HSATII satellite transcripts per million transcripts in a noncancerous reference sample comprising pancreatic cells;
- detecting an increase in the test value compared to the level of total HSATII satellite transcripts per million transcripts in the noncancerous reference sample, wherein the increase indicates that the subject has pancreatic cancer;
- and administering to the subject a surgical intervention, chemotherapy, radiation therapy, or a combination thereof.
1 more element
Dependencies are inferred from the claim text.