Stromal stem cells
AssigneeOrbsen Therapeutics Limited
InventorStephen J. Elliman
Life of this patent
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Abstract
Stromal stem cells are prospectively isolated from human bone marrow then expanded into clonal populations and cultured and used, the isolation being on the basis of expression of a cell surface marker, wherein the cell surface marker binds an antibody and wherein said antibody cross reacts with a cell surface marker found on mouse stromal stem cells or rat stromal stem cells, and optionally also on a cell of at least one other mammalian species selected from mouse, rat, horse, rabbit and pig cells. Useful stromal stem cell populations are positive for SDC2.
Claims19
A method of treating an inflammatory disease in an individual, comprising administering to the individual a composition comprising a population of mammalian stromal stem cells and a pharmaceutically acceptable carrier, wherein 30% or more of the cells are positive for SDC2 and wherein the inflammatory disease is a liver disease or a diabetes related disease.
Dependencies are inferred from the claim text.