Loading platform for three-dimensional tissue engineered scaffolds
AssigneeThe University of Toledo
InventorsGayathri Subramanian, Mostafa Elsaadany, Eda Yildirim-Ayan
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Abstract
A scaffold-stretching system includes at least one stretchable loading chamber configured to support a scaffold material and a supply of cells, such as human skin substitute cells, and is configured to allow for cultivation of a cellular three-dimensional scaffold; and a mechanical loading system is configured for application of cyclic and static uniaxial tensile mechanical loading on the cellular three-dimensional scaffold, and is configured to mimic the in vivo environment of musculoskeletal, cardiovascular, and other tissues that experience uniaxial strains.
Claims17
A scaffold-stretching system comprising:
- at least one stretchable loading chamber;
- at least one scaffold material supported by the stretchable loading chamber;
- the stretchable loading chamber including at least one groove on a top surface of the stretchable loading chamber, the groove having opposing linear portions that are connected by opposing semi-circular portions;
- wherein the semicircular portions of the groove link opposing linear portions of the scaffold material, and provide mechanical support and stability during stretching;
- wherein the scaffold material is capable of receiving supply of cells, and allowing for cultivation of a cellular three-dimensional scaffold in the scaffold material;
- and
- at least one mechanical loading system configured for application of for applying cyclic and static uniaxial tensile mechanical loading on the cultivating cellular three-dimensional scaffold, and mimicking the in vivo environment of musculoskeletal, cardiovascular, and other tissues that experience uniaxial strains.
Dependencies are inferred from the claim text.