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US 11,142,586 B2Granted
Anti-human nicotinamide phosphoribosyltransferase (NAMPT) antibodies
AssigneeAqualung Therapeutics
InventorsJoe G. N. Garcia, Darragh MacCann
Life of this patent
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Abstract
Anti-nicotinamide phosphoribosyltransferase (NAMPT) antibodies, or antigen binding fragments thereof, are described, as well as methods for treating a subject having a (NAMPT)-associated local and/or systemic inflammatory disorder.
Claims17
An isolated antibody, or an antigen-binding fragment thereof, that binds to human nicotinamide phosphoribosyltransferase (NAMPT), said antibody or antigen-binding fragment thereof comprising:
- (a) a heavy chain variable region comprising a CDR1 domain having an amino acid sequence as set forth in SEQ ID NO:
- 3;
- a CDR2 domain having an amino acid sequence as set forth in SEQ ID NOs:
- 4 or 29;
- and a CDR3 domain having an amino acid sequence as set forth in SEQ ID NO:
- 5;
- and
- (b) a light chain variable region comprising a CDR1 domain having an amino acid sequence as set forth in SEQ ID NO:
- 6 or 11;
- a CDR2 domain having an amino acid sequence as set forth in SEQ ID NO:
- 7, 12, 14, 33, 35 or 37;
- and a CDR3 domain having an amino acid sequence as set forth in SEQ ID NO:
- 8.
10 more elements
Dependencies are inferred from the claim text.