Anti-ERBB-2 antibodies and uses thereof
AssigneeAgency for Science, Technology and Research
InventorsHeng Liang Tan, Andre Boon Hwa Choo
Life of this patent
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Abstract
The present invention relates to antigen-binding proteins, or antigen-binding fragments thereof. In particular, the present invention relates to antigen-binding proteins, or antigen-binding fragments thereof that bind to ERBB2. Compositions comprising a physiologically acceptable carrier and a therapeutically effective amount of the antigen-binding protein, or antigen-binding fragment thereof, use of the antigen-binding protein, or antigen-binding fragment thereof, methods for detecting cancer as well as kits when used in such methods are also provided.
Claims12
An antigen-binding protein, or an antigen-binding fragment thereof, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GYTFSNYWIE (SEQ ID NO:
- 3);
- a VHCDR2 having the amino acid sequence EILPGSDSTNYNEKFKG (SEQ ID NO:
- 4), and a VHCDR3 having the amino acid sequence GGSNYGYYFDY (SEQ ID NO:
- 5);
- and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KASQDVGTAVA (SEQ ID NO:
- 6), a VLCDR2 having the amino acid sequence WASTRHT (SEQ ID NO:
- 7), and a VLCDR3 having the amino acid sequence QQYSSYRT (SEQ ID NO:
- 8).
A method of treating cancer comprising administering an antigen-binding protein, or an antigen-binding fragment thereof, to a subject in need thereof, wherein the antigen-binding protein, or an antigen-binding fragment thereof, comprises (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GYTFSNYWIE (SEQ ID NO:
- 3);
- a VHCDR2 having the amino acid sequence EILPGSDSTNYNEKFKG (SEQ ID NO:
- 4), and a VHCDR3 having the amino acid sequence GGSNYGYYFDY (SEQ ID NO:
- 5);
- (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KASQDVGTAVA (SEQ ID NO:
- 6), a VLCDR2 having the amino acid sequence WASTRHT (SEQ ID NO:
- 7), and a VLCDR3 having the amino acid sequence QQYSSYRT (SEQ ID NO:
- 8), and the antigen-binding protein, or antigen-binding fragment thereof, further comprising a radioisotope or a cytotoxin conjugated thereto.
Dependencies are inferred from the claim text.