Anti-CD40 antibodies and uses thereof

An antibody or antigen-binding fragment thereof that binds to CD40 (TNF Receptor Superfamily Member 5) comprising:

• a heavy chain variable region (VH) comprising complementarity determining regions (CDRs) 1, 2, and 3, wherein the VH CDR1 region comprises an amino acid sequence that is identical to a selected VH CDR1 amino acid sequence, the VH CDR2 region comprises an amino acid sequence that is identical to a selected VH CDR2 amino acid sequence, and the VH CDR3 region comprises an amino acid sequence that is identical to a selected VH CDR3 amino acid sequence;
• and
• a light chain variable region (VL) comprising CDRs 1, 2, and 3, wherein the VL CDR1 region comprises an amino acid sequence that is identical to a selected VL CDR1 amino acid sequence, the VL CDR2 region comprises an amino acid sequence that is identical to a selected VL CDR2 amino acid sequence, and the VL CDR3 region comprises an amino acid sequence that is identical to a selected VL CDR3 amino acid sequence,
• wherein the selected VH CDRs 1, 2, and 3 amino acid sequences and the selected VL CDRs, 1, 2, and 3 amino acid sequences are one of the following:
• (1) the selected VH CDRs 1, 2, 3 amino acid sequences are set forth in SEQ ID NOs:
• 1, 2, 3, respectively, and the selected VL CDRs 1, 2, 3 amino acid sequences are set forth in SEQ ID NOs:
• 4, 5, 6, respectively;
• (2) the selected VH CDRs 1, 2, 3 amino acid sequences are set forth in SEQ ID NOs:
• 19, 20, 3, respectively, and the selected VL CDRs 1, 2, 3 amino acid sequences are set forth in SEQ ID NOs:
• 4, 21, 6, respectively;
• (3) the selected VH CDRs 1, 2, 3 amino acid sequences are set forth in SEQ ID NOs:
• 7, 8, 9, respectively, and the selected VL CDRs 1, 2, 3 amino acid sequences are set forth in SEQ ID NOs:
• 10, 11, 12, respectively;
• (4) the selected VH CDRs 1, 2, 3 amino acid sequences are set forth in SEQ ID NOs:
• 22, 23, 9, respectively, and the selected VL CDRs 1, 2, 3 amino acid sequences are set forth in SEQ ID NOs:
• 10, 11, 12, respectively;
• (5) the selected VH CDRs 1, 2, 3 amino acid sequences are set forth in SEQ ID NOs:
• 13, 14, 15, respectively, and the selected VL CDRs 1, 2, 3 amino acid sequences are set forth in SEQ ID NOs:
• 16, 17, 18, respectively;
• and
• (6) the selected VH CDRs 1, 2, 3 amino acid sequences are set forth in SEQ ID NOs:
• 24, 25, 15, respectively, and the selected VL CDRs 1, 2, 3 amino acid sequences are set forth in SEQ ID NOs:
• 16, 17, 18, respectively.