Back to results
US 11,142,577 B2Granted
WNT signaling agonist molecules
AssigneesThe Board of Trustees of the Leland Stanford Junior University, University of Washington
InventorsKenan Christopher Garcia, David Baker, Claudia Yvonne Janda, Luke Dang, James Daniel Moody
Life of this patent
Estimating the term…
Abstract
Wnt signaling agonist compositions and methods for their use are provided. Wnt signaling agonists of the invention comprise a frizzled binding moiety, which is fused or conjugated to an LRP5 or LRP6 binding moiety.
Claims5
A water soluble canonical Wnt signaling agonist that dimerizes a Frizzled (Fzd) receptor with Lrp5/6,
- wherein the Wnt signaling agonist comprises a Fzd binding domain and a Lrp5/6 binding domain;
- wherein the Fzd binding domain comprises the amino acid sequence set forth in SEQ ID NO:17 or SEQ ID NO:18, and binds one or more Fzd proteins;
- wherein the Lrp5/6 binding domain comprises DKK-1 C-terminal domain;
- and wherein the Fzd binding domain and the Lrp5/6 binding domain are joined through a linker that enforces a distance between the Fzd binding domain and the Lrp5/6 binding domain of less than about 100 angstroms.
1 more element
Dependencies are inferred from the claim text.