Anti-integrin β1 antibody compositions and methods of use thereof
AssigneeOncosynergy, Inc.
InventorW. Shawn Carbonell
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Abstract
The current invention provides human variable chain framework regions and humanized antibodies comprising the framework regions, the antibodies being specific for integrin β1. The invention also provides methods for utilizing the antibodies, for example to treat diseases such as cancer.
Claims24
A humanized antibody which specifically binds integrin β1 comprising a heavy chain variable (VH) region and a light chain variable (VL) region, wherein the VH region has about 90-96% identity to a VH region having an amino acid sequence as set forth in SEQ ID NO:2 and wherein the VL region has about 84-92% identity to a VL region having an amino acid sequence as set forth in SEQ ID NO:4;
- and wherein the CDR regions comprise SEQ ID NO:23-28.
Dependencies are inferred from the claim text.