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US 11,142,574 B2Granted
Anti-TIM-3 antibodies
AssigneeAgency for Science, Technology and Research
InventorsCheng-I Wang, Hsueh Ling Janice Oh, Siok Ping Yeo, Yun Pei Sharon Goh
Life of this patent
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Abstract
Anti-TIM-3 antibodies are disclosed. Also disclosed are pharmaceutical compositions comprising such antibodies, and uses and methods using the same.
Claims12
A method of treating cancer, comprising administering an antibody or antigen binding fragment to a patient suffering from the cancer, wherein the antibody or antigen binding fragment is capable of binding to TIM-3 and comprises at least one light chain variable region incorporating the following CDRs:
- LC-CDR1:
- (SEQ ID NO:
- 47)
- SGSSSNIGNNYVS
- LC-CDR2:
- (SEQ ID NO:
- 48)
- GNNWRPS
- LC-CDR3:
- (SEQ ID NO:
- 49)
- ETWDSSLSAGV;
- at least one heavy chain variable region incorporating the following CDRs:
- HC-CDR1:
- (SEQ ID NO:
- 61)
- GYYWS,
- or
- (SEQ ID NO:
- 52)
- GGSFSGYYWS
- HC-CDR2:
- (SEQ ID NO:
- 53)
- EINHSGSTNYNPSLKS
- HC-CDR3:
- (SEQ ID NO:
- 54)
- GYVAGFDY.
26 more elements
Dependencies are inferred from the claim text.