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US 11,142,571 B2Granted
IL-6 antibodies
AssigneeSesen Bio, Inc.
InventorsMichael March Schmidt, Alison Tisdale, Eric Steven Furfine, Grigorios Zarbis-Papastoitsis
Life of this patent
Estimating the term…
Abstract
Improved IL-6 antibodies are provided. Uses of the antibodies in the treatment of IL-6-related diseases, e.g., ocular diseases such as diabetic macular edema, are disclosed.
Claims35
An isolated anti-IL-6 antibody or antigen binding fragment thereof comprising:
- a) a heavy chain variable (VH) domain comprising a VH CDR1 comprising the sequence of SEQ ID NO:31, a VH CDR2 comprising the sequence of SEQ ID NO:32, and a VH CDR3 comprising the sequence of SEQ ID NO:33, and
- b) a light chain variable (VL) domain comprising a VL CDR1 comprising the sequence of SEQ ID NO:34, a VL CDR2 comprising the sequence of SEQ ID NO:35, and a VL CDR3 comprising the sequence of SEQ ID NO:36.
An isolated anti-IL-6 antibody or antigen binding fragment comprising a heavy chain sequence comprising SEQ ID NO:
- 47 and a light chain sequence comprising SEQ ID NO:42.
Dependencies are inferred from the claim text.