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US 11,142,565 B2Granted
Broadly neutralizing anti-HIV-1 antibodies that bind to an N-glycan epitope on the envelope
AssigneeAbVitro LLC
InventorsFrancois Vigneault, Adrian Wrangham Briggs, Stephen J. Goldfless, Sonia Timberlake
Life of this patent
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Abstract
This invention relates to novel anti-HIV antibodies that can be used in the treatment and detection of human immunodeficiency virus (HIV). These antibodies exhibit a high degree of sensitivity and can provide a broad range of specificity.
Claims24
An antibody or antigen-binding fragment thereof that specifically binds to an N-glycan epitope of HIV-1 Env, comprising:
- (a) a heavy chain variable domain (VH) comprising:
- a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
- 17, a CDR-H2 comprising the amino acid sequence of SEQ ID NO:
- 18, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO:
- 19;
- and
- (b) a light chain variable domain (VL) comprising:
- a CDR-L1 comprising the amino acid sequence of SEQ ID NO:
- 20, a CDR-L2 comprising the amino acid sequence of SEQ ID NO:
- 21, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO:
- 22.
8 more elements
Dependencies are inferred from the claim text.