Broadly-neutralizing anti-HIV antibodies
AssigneesThe Rockefeller University, California Institute of Technology
InventorsHugo Mouquet, Michel Nussenzweig, Pamela J. Bjorkman, Louise Scharf
Life of this patent
Estimating the term…
Abstract
The present invention relates to anti-HW antibodies. Also disclosed are related methods and compositions. HIV causes acquired immunodeficiency syndrome (AIDS), a condition in humans characterized by clinical features including wasting syndromes, central nervous system degeneration and profound immuno suppression that results in life-threatening opportunistic infections and malignancies. Since its discovery in 1981, HIV type 1 (HIV-1) has led to the death of at least 25 million people worldwide.
Claims12
An isolated anti-HIV antibody, or antigen binding portion thereof, comprising (i) a heavy chain region that comprises CDRH 1, CDRH 2, CDRH 3 and (ii) a light chain region that comprises CDRL 1, CDRL 2 and CDRL 3, wherein said CDRH 1, CDRH 2, CDRH 3, CDRL 1, CDRL 2, and CDRL 3 comprise the sequences of SEQ ID NOs:
- 57-62, respectively.
Dependencies are inferred from the claim text.