Tumor necrosis factor receptor (TNFR) binding protein complex with improved binding and bioactivity
AssigneeUniversität Stuttgart
InventorsRoman Fischer, Roland Kontermann, Klaus Pfizenmaier, Martin Siegemund
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Abstract
The present invention relates to a tumor necrosis factor receptor (TNFR) binding protein complex comprising 12 or more protein ligands (PLs) that specifically bind to the extracellular part of the same TNFR. Preferably, the TNFR binding protein complex binds to the extracellular part of TNFR2. Preferably, the TNFR binding protein complex of the present invention further comprises two or more polymerization domains (PD).
Claims19
A tumor necrosis factor receptor (TNFR) binding protein complex comprising 12 or more protein ligands (PLs) that specifically bind to the extracellular part of the same TNFR.
Dependencies are inferred from the claim text.