Neuropeptide S receptor (NPSR) agonists
AssigneeResearch Triangle Institute
InventorsScott Runyon, Carla Hassler, Craig Shiner, Sanju Narayanan
Life of this patent
Estimating the term…
Abstract
Neuropeptide S receptor agonists are provided. The NPS agonists include peptidomimetic analogs exhibiting affinity for and activity at the neuropeptide S receptor. The molecules may be useful in the treatment of disorders, syndromes and conditions mediated by modulation of the neuropeptide S receptor such as substance abuse, narcolepsy, insomnia, obesity, cognitive decline, dementia, Alzheimer's disease, panic disorder, generalized anxiety, PTSD, phobias, schizophrenia and as supportive medication during any kind of cessation program in cognitive behavioral therapy, such as drug addiction, eating disorders and gambling.
Claims22
A compound of Formula I:
- wherein:
- R1 is selected from phenyl, benzyl, benzyloxy, phenethyl, C1-C4 alkylcycloalkyl, benzamido, polycyclic heterocycle, or branched or unbranched C1-C6 alkyl;
- R2 is selected from benzyl;
- R3 is H, benzyl, or lysine side chain;
- R4 is
- (a) a five membered saturated ring substituted with one C(O)NH2 group;
- (b) a six membered saturated or aromatic ring substituted with one C(O)NH2 group,
- (c) C1-C3 amidoalkyl;
- and
- R5 is H or C1-C6 alkyl;
- or a pharmaceutically acceptable salt thereof.
The compound selected from Formula II:
- wherein
- R1′ is phenyl;
- R2′ is benzyl;
- A, A′ and A″ are independently selected from —NH— or —O—, provided that at least one of A, A′ and A″ is —O—;
- R3′ is H, benzyl or lysine side chain;
- and
- R4′ is a five membered saturated ring substituted with one C(O)NH2 group or a six membered saturated or aromatic ring substituted with one C(O)NH2 group;
- or a pharmaceutically acceptable salt thereof.
A compound:
- or a pharmaceutically acceptable salt thereof.
A compound:
- or a pharmaceutically acceptable salt thereof.
A compound:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.