Antidepressant compound and preparation method and application thereof

A compound of formula (I), or a pharmaceutically acceptable salt, a solvate, an optically pure isomer or a stereoisomer thereof, or a mixture thereof,

• wherein the compound of formula (I) is formed by linking the following fragment A and fragment B,
• wherein, R1, R2 and R3 are each independently selected from the group consisting of H, alkyl, substituted alkyl, arylalkyl, substituted arylalkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclyl, and substituted heterocyclyl, provided that R2 or R3 is other than an adamantyl;
• or R2, R3 and attached N together form 3-7 membered saturated or unsaturated heterocycle containing 1-3 N, 0-2 O and/or 0-2 S atoms, wherein the “heterocycle” is unsubstituted, monosubstituted or polysubstituted by the following group(s):
• H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, alkanoyl, substituted alkanoyl, alkoxycarbonyl, arylalkoxycarbonyl, alkylsulfonyl, alkylsulfinyl, arylsulfonyl, arylalkylsulfonyl, carbamoyl, substituted carbamoyl, carboxyl, amido, substituted amido, sulfonamido, and substituted sulfonamide;
• R4a and R4b are each independently selected from the group consisting of hydrogen, hydroxy, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, and substituted alkynyl;
• or R4a, R4b and attached C together form 3-7 membered saturated or unsaturated heterocycle containing 0-3 N, 0-2 O and/or 0-2 S atoms, wherein the “heterocycle” is unsubstituted, monosubstituted or polysubstituted by the following group(s):
• hydrogen, hydroxy, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, and substituted alkynyl;
• X1 is O, S or NR5, R5 is selected from the group consisting of hydrogen, alkyl, cyano, hydroxy, and alkoxy;
• X2 is O or NH;
• R6a, R6b, R6c, R6d, R6e, R6f, R7a, R7b, R8a, R8b, R9a, R9b, R10a, and R10b are each independently selected from the group consisting of absent, hydrogen, halogen, alkyl, substituted alkyl, hydroxy, mercapto, alkylmercapto, alkoxy, substituted alkoxy, amino, substituted amino, alkylamino, substituted alkylamino, disubstituted amino, alkylacyloxy, arylacyloxy, heteroarylacyloxy and glycosyl;
• or R6a and R6b, R7a and R7b, R8a and R8b, R9a and R9b, and/or R10a and R10b are combined with each other to form carbonyl;
• “” represents a single bond or double bond;
• and
• each * independently represents a racemic, S or R configuration.