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US 11,142,539 B2Granted
Phosphinogold(I) complexes and methods of treating cancer
AssigneesKing Fahd University of Petroleum and Minerals, King Saud University
InventorsAnvarhusein A. Isab, Adam Ahmed Abdullah Sulaiman, Ali Alhoshani
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Abstract
Mixed ligand phosphinogold(I) complexes as anticancer agents. The gold(I) ion of the complexes is coordinated to a phosphine and a dithiocarbamate or halogen ligand. Also described are a pharmaceutical composition incorporating the phosphinogold(I) complex, a method of synthesizing the phosphinogold(I) complex, and a method of treating cancer. The phosphinogold(I) complexes exhibit potent cytotoxicity against lung, cervical, and liver cancer cells.
Claims20
A gold(I) complex of formula (I)
- or a salt thereof, a solvate thereof, a tautomer thereof, a stereoisomer thereof, or a mixture thereof,
- wherein:
- R1 and R2 are each independently an optionally substituted aryl;
- R3 is selected from the group consisting of —OH, —OCH3, —NH2, and —N(CH3)2;
- R4 is a halogen or
- and
- n is an integer in a range of 1-3,
- wherein R5 and R6 are each independently selected from the group consisting of a hydrogen, an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted arylalkyl, and an optionally substituted aryl.
5 more elements
Dependencies are inferred from the claim text.