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US 11,142,516 B2Granted
Process for the preparation of an amino-pyrimidine and intermediates thereof
AssigneeCytokinetics, Inc.
InventorsMatthew Peterson, Kevin Lu, Bradley Morgan, David Morgans, Tohru Fukuyama
Life of this patent
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Abstract
Provided herein is a novel process for the preparation of an amino-pyrimidine and salts thereof. Also provided herein are novel intermediates used in this process and their preparation.
Claims29
A method of preparing a compound of Formula (1):
- or a salt thereof, comprising:
- (i) reacting a compound of Formula (1A):
- with 2-chloro-3-fluoropyridine to form a compound of Formula (1B):
- (ii) reacting the compound of Formula (1B) with an aqueous acid to form a compound of Formula (1C):
- and
- (iii) converting the compound of Formula (1C) to the compound of Formula (1) or a salt thereof.
3 more elements
A compound of Formula (1B):
- or a salt thereof.
A method of preparing a compound of Formula (1B):
- or a salt thereof, comprising:
- reacting a compound of Formula (1A):
- with 2-chloro-3-fluoropyridine to form the compound of Formula (1B).
A compound of Formula (1D):
- or a salt thereof.
A method of preparing a compound of Formula (1D):
- or a salt thereof, comprising converting a compound of Formula (1E):
- to the compound of Formula (1D) or a salt thereof.
Dependencies are inferred from the claim text.