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US 11,142,512 B2Granted
Nebivolol synthesis method and intermediate compound thereof
AssigneeZhejiang Ausun Pharmaceutical Co., Ltd.
InventorZhiguo Zheng
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Abstract
The present invention relates to nebivolol synthesis method and intermediate compound thereof. Specifically, the present invention relates to a method for synthesizing nebivolol, intermediate compound thereof, and a method for preparing the intermediate compound.
Claims15
A compound of formula III
- wherein R is hydroxy-protecting group, which is selected from alkyl, haloalkyl, aralkyl, alkoxyalkyl, allyl, t-BuPh2Si, (i-Pr)3Si, and Et3Si.
A compound of formula IV1′
- wherein Ra is a is hydroxy-protecting group, which is selected from aralkyl, alkoxyalkyl, allyl, t-BuPh2Si, (i-Pr)3Si, and Et3Si.
A compound of formula IV2′
- wherein Rb is hydrogen or Rb is hydroxy-protecting group, which is selected from aralkyl, alkoxyalkyl, allyl, t-BuPh2Si, (i-Pr)3Si, and Et3Si.
Dependencies are inferred from the claim text.