US 11,142,505 B2Granted

Compositions for APP-selective BACE inhibition and uses therefor

AssigneeThe Regents of the University of California

InventorsVarghese John, Patricia Spilman, Barbara Jagodzinska

Life of this patent

Estimating the term…

Abstract

Selected compounds, compositions, and methods for inhibiting BACE are presented that have relatively high selectivity towards APP via interaction of the inhibitor with both BACE and APP.

Claims20

Dependent claims

A compound having a structure according to any one of Formula IV-Formula X:

Dependencies are inferred from the claim text.

Facts

Application: 15/755,496Filed 29 Aug 2016 · us provisional application
Priority: 27 Aug 2015
Published: US 2019/0077766 A114 Mar 2019
Granted: 12 Oct 2021
Term ends: Not estimatedThe source records don’t support an estimate.

Classification20 codes

C07D 233/88
With hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals,…:…
A61P 25/28
Drugs for disorders of the nervous system: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents,…
C07D 401/04
Containing two hetero rings: directly linked by a ring-member-to-ring-member bond
C07D 401/06
Containing two hetero rings: linked by a carbon chain containing only aliphatic carbon atoms

Family

Application62/210,945Us provisional application · filed 27 Aug 2015
US 2019/0077766 A1Pre-grant publication · published 14 Mar 2019
US 11,142,505 B2This patent

From the US filing history. Foreign family members aren’t listed.

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