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US 11,142,502 B2Granted
(+)-morphinans as antagonists of Toll-like receptor 9 and therapeutic uses thereof
AssigneeMallinckrodt Inc.
InventorBobby N. Trawick
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Abstract
The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat pain. Also provided are pharmaceutical combination compositions comprising a (+)-morphinan and an opioid agonist/monoamine reuptake inhibitor, as well as methods for using the combination compositions to treat pain.
Claims12
A method for treating stroke in a subject in need thereof, the method comprising administering to the subject a compound of Formula (IIb) or a pharmaceutically acceptable salt thereof:
- wherein:
- R is hydrogen, alkyl, allyl, or cycloalkylmethyl;
- Ra is hydrogen, alkyl, or phenyl;
- Rb is hydrogen, alkyl, alkylalcohol, alkylcarboxyl, alkylcarboxylalkylester, acyl, acylalkyl, acylaryl, acyloxy, acyloxyalkyl, or acyloxyaryl;
- and
- Y is hydrogen or hydroxy.
3 more elements
Dependencies are inferred from the claim text.